Personalized GLP-1 Weight Loss Medications

Personalized GLP-1 Weight Loss Medications

  • Clinically Proven weight loss solutions

  • No Membership Fees

  • Online care from start to finish

  • FSA / HSA Eligible

Semaglutide
Compounded

As low as

$179 / Month

  • Transparent pricing with no hidden fees

  • No insurance needed

  • Doctor prescribed

  • FSA/HSA Eligible

Tirzepatide
Compounded

As low as

$269 / Month

  • Transparent pricing with no hidden fees

  • No insurance needed

  • Doctor prescribed

  • FSA/HSA Eligible

Semaglutide
Oral

As low as

$209 / Month

  • Transparent pricing with no hidden fees

  • No insurance needed

  • Doctor prescribed

  • FSA/HSA Eligible

Patients must qualify for personalized GLP-1 therapy

Nucore Testimonial 1

Why Consider GLP-1 Receptor Agonists for Weight Loss?

GLP-1 receptor agonists are a highly effective class of medications used for managing Type 2 diabetes and promoting weight loss. These medications work by mimicking naturally occurring hormones in your body, which play a fundamental role in regulating blood sugar, slowing digestion to enhance feelings of fullness, and reducing appetite and cravings by acting on the brain. These combined effects contribute to meaningful metabolic improvement and can lead to sustainable weight loss.

While individual GLP-1 receptor agonists may vary in their specific applications (some are approved primarily for diabetes, others for chronic weight management), their core mechanism of action offers a powerful approach to supporting weight loss efforts.

GLP-1 Clinical outcome studies:

  • Studies have demonstrated a 20% reduction in major adverse coronary events (MACE) associated with GLP-1 usage. Article
  • An average reduction in A1C of 1-1.7% is commonly observed in patients with type 2 diabetes. Article
  • Patients typically experience a 15-20% reduction in total body weight. Article 1 : Article 2

Revolutionary Weight Loss Medications: Affordable GLP-1 Treatments

Nucore offers affordable versions of the most effective glucagon-like peptide-1 (GLP-1) receptor agonist medications, including compounded semaglutide and compounded tirzepatide. These medications are proven to:

  • Reduce appetite and cravings by acting on the brain’s hunger centers.
  • Improve insulin sensitivity, making it easier for the body to utilize stored fat.
  • Enhance fat metabolism while preserving lean muscle mass.
  • Regulate blood sugar levels, reducing the risk of metabolic disorders.

Studies show that GLP-1 medications can help patients lose 15-22% of their body weight over 12-18 months, significantly more than conventional diet and exercise alone. However, at Nucore, we don’t just prescribe medication. Our approach ensures proper dosing, medical monitoring and personalized metabolic optimization to maximize results.

Transform Your Metabolism For Life

You’ve likely tried countless diets and exercise routines and may feel frustrated when weight loss remains elusive. Often, the missing piece is addressing the biological factors at play. Hormonal imbalances, metabolic dysfunction and insulin resistance can work against you. At Nucore, we’re here to help you understand these factors and provide practical, science-backed solutions to overcome weight loss resistance and reclaim your vitality.

Frequently Asked Questions

A: Weight loss can vary among patients. Some notice weight loss right away, others can take one month or more. Consistency is important. Continue to take as directed and your provider will titrate your dose as needed to promote optimal weight loss tailored to your clinical needs. On average, 1-2 pounds per week (or 6-8 pounds per month) of weight loss is typically considered safe. That said, individual targets may vary and should be discussed with your weight management clinician. Please note that prior to every visit, you will need an updated weight, blood pressure and heart rate measurement.

A: Branded GLP-1s, renowned for their groundbreaking applications in diabetes management, have emerged as a promising and innovative solution for individuals seeking effective and sustainable weight loss. Engineered by leading pharmaceutical companies, these GLP-1 receptor agonists harness the power of Glucagon-Like Peptide-1 to not only regulate blood sugar levels but also to address the intricate interplay between metabolism and body weight.

The distinct feature that sets these branded GLP-1s apart in the realm of weight management is their ability to influence satiety and reduce appetite. The drugs work by mimicking GLP-1, a gut hormone produced naturally by your body that is involved in insulin release and appetite regulation. GLP-1 medications have been shown to encourage insulin release after you eat, while also inhibiting glucagon production and slowing down digestion. Together, these effects help to control blood sugar, reduce appetite, and lead to weight loss.

The medications are often accompanied by user-friendly delivery methods such as injectable pens. Currently, some GLP-1 medications are only FDA-approved to manage blood sugar levels or reduce cardiovascular risk in people with type 2 diabetes, like Ozempic and Mounjaro. Others, including Zepbound, Wegovy and Saxenda, are specifically approved for weight loss. However, health providers may prescribe medications like Ozempic and Mounjaro off-label for weight loss, if they feel the drug is the best option for their patient.

A: Drug compounding is often regarded as the process of combining, mixing or altering ingredients to create a medication tailored to the needs of an individual patient. Compounding includes the combining of two or more drugs. Compounded drugs are not FDA-approved. That said –

  • We ensure that the ingredients used in the prescribed GLP-1 compounds are pharmaceutical grade and NOT research grade.
  • We ensure that the GLP-1 medication is compounded using its base form and NOT its salt form.
  • The compounding pharmacy conducts third-party quality testing to check for potency, sterility and the presence of toxins.
  • We ensure complete due diligence of the compounding pharmacy, including but not limited to accreditations, licensures, and manufacturing/storage/tracking processes.

A: GI side effects are most common when initiating GLP-1 therapy. Nausea, diarrhea, constipation and lack of appetite are among the most common. Your provider may be able to prescribe medication to help manage these side effects. Often these side effects resolve over time.

A: GLP-1 therapy can help with weight loss by making you feel full and reducing appetite. GLP-1 is a hormone that our bodies naturally produce. When we eat food, GLP-1 is released and tells our brains that we’re full. With GLP-1 therapy, doctors give you a medicine called a GLP-1 agonist. This medicine works like the natural GLP-1 in your body. It tells your brain that you’re full even if you haven’t eaten as much food. This can help you eat less and make healthier food choices. When you eat less and make healthier choices, you can lose weight over time.

A: There are two ways GLP-1 medications are administered: orally and via injection. The injectable method is currently more common and is administered with a small insulin needle. You can inject this below the level of the skin in your abdomen, the outside of your thigh, or the outside of your upper arm. These are given once a week. Check out this helpful guide on giving a subcutaneous injection from the University of Michigan. Oral medications are taken daily.

A: Video: Ozempic® (semaglutide) injection 0.5 mg, 1 mg, or 2 mg Pen Instructions for Use | novoMEDLINK™

A: How to inject compounded tirzepatide

A: Yes, GLP-1 therapy can be combined with many other chronic medications such as those used for diabetes, blood pressure and high cholesterol. That said, there are certain medications and conditions which are not a good fit for GLP-1 therapy. It is important to notify both your PCP and your weight management clinician of any medications added or removed so they can continue to follow your progress and make other medication adjustments as needed.

A: When you’re on GLP-1 therapy, there are some simple lifestyle changes that can help you stay healthy and get the best results from the medicine. These include eating healthy foods, drinking plenty of water, listening to your healthcare provider, and sleeping well. Remember, GLP-1 therapy can be helpful, but it’s just one part of taking care of yourself. Making healthy choices with food, exercise and sleep will make you feel strong and happy. And don’t forget to have fun and enjoy life with your friends and family!

A: Yes, there may be interactions with your current medications. This is why it is important to list ALL of your medications AND supplements for your weight loss provider to review. Additionally, it is important to notify your in-person healthcare providers of any GLP-1 added so they do not start you on a medication that is contraindicated while on GLP-1 therapy.

What can I expect from my initial level of medication in terms of weight loss?

Please note that the initial level of medication is usually intended to be a starter dose to help your body get used to to the mechanism and effects of the medicine in association with a balanced diet and lifestyle program. It is common to not see significant weight loss on this level, but it is important for the reasons mentioned above. At your subsequent visit, your provider will evaluate your progress and increase the level of your medication if appropriate.

A: Patients will notice an immediate weight loss and others will require higher doses of medication to achieve weight loss. Continue to use your medication as prescribed and your provider will titrate as necessary to promote weight loss

A: Most people find that side effects decrease over time. If you are finding it hard to manage side effects, please mention this to your provider.

A: Exercise 3-5 days a week, drink plenty of water, and eat a well-balanced diet. Smaller portion sizes can help reduce excess calorie consumption.

As far as healthy eating goes, patients are not required to follow a specific diet, but it is important that you implement a reduced-caloric diet. Here are some recommendations:

  • Decrease calories and work up to a ~500 kcal daily energy deficit
  • Consider intermittent fasting (IF), including time-restricted eating (TRE) and intermittent calorie restriction (ICR)
  • Eating plans such as the DASH (Dietary Approaches to Stop Hypertension) diet, Therapeutic Lifestyle Changes diet, the Mediterranean Diet, or following the American Heart Association (AHA) 2021 Dietary Guidance to Improve Cardiovascular Health are all worth considering
  • If you need assistance with meal planning or have special dietary needs, it may be helpful to seek guidance from a registered dietitian
  • Include a wide variety of nutrient-dense foods, such as fruits, vegetables, lean meats, low-fat dairy, seafood, nuts, seeds, legumes and whole grains
  • Replace foods that are high in cholesterol, saturated fat (animal fats) and trans fats (fried, processed foods) with foods that are high in monounsaturated and polyunsaturated fats like olive oil, nuts, seeds and avocado
  • Minimize refined carbohydrates, sweets and sugar-sweetened beverages
  • If you cannot eat at least 1,200 calories each day, a multivitamin may be needed to ensure you’re meeting your nutritional needs
  • After you reach your weight loss goal, it’s important to continue a healthy eating pattern to avoid weight regain

A: If you miss more than 2 weeks of a GLP-1 medication, we suggest reinitiating the dosing schedule to reduce the chance of GI side effects. For example, if you are on level 3 of Ozempic, but have missed 3 weeks due to a shortage or being out of town, we would restart you on level 1.

A: Once you reach a BMI of 25, your weight management clinician will start to de-escalate your dose. Once your BMI is between 22-24, you should ideally be at the lowest dose of medication. If you start to regain weight, your weight management clinician can begin to escalate the dose. It is recommended that you continue living a healthy lifestyle to maintain your weight loss.

A: For GLP-1 medications, follow-ups are recommended at 1-month intervals until you have reached a steady state, at which time you will meet with your provider every 3 months.

Medical & Disclaimer Information:

Compounded medications offered through NuCore Health have not been reviewed or approved by the FDA for safety, efficacy, or quality. NuCore Health programs take a holistic approach, incorporating provider-prescribed compounded medications along with personalized support and guidance tools. Individual results may vary. Product packaging may differ from images or descriptions.

GLP-1 receptor agonists are powerful prescription treatments typically prescribed for adults with a Body Mass Index (BMI) of 30 or greater (indicating obesity), or a BMI of 27 or greater (indicating overweight) when accompanied by at least one weight- related health condition such as high blood pressure, type 2 diabetes, or high cholesterol.

These medications are not suitable if you have:

  • A personal or family history of medullary thyroid carcinoma (MTC), a rare type of
    thyroid cancer.
  • Multiple Endocrine Neoplasia syndrome type 2 (MEN 2), a genetic condition.
  • Are pregnant, planning to become pregnant, or are breastfeeding.

Always have an open and comprehensive discussion with your Nucore Health licensed provider about your complete medical history before beginning any new therapy.

Understanding Potential Side Effects:

Like all medications, GLP-1s can cause side effects. Most are generally mild and temporary, often improving as your body gradually adjusts to the treatment. Common side effects may include:

  • Nausea
  • Diarrhea
  • Constipation
  • Abdominal discomfort
  • Reduced appetite
  • Reactions at the injection site (such as redness or swelling)

Your dedicated Nucore Health clinical team is committed to your well-being. We will work closely with you to monitor any side effects, adjust your dosing as needed, and ensure your experience is as safe and supportive as possible.

Compounded semaglutide has not been approved by the U.S. Food and Drug Administration (FDA). The FDA does not verify the safety, effectiveness, or quality of compounded drugs.

To receive any prescription product, you must complete an online consultation with a healthcare provider, who will determine if a prescription is appropriate for you.

Wegovy® (semaglutide) and Ozempic® (semaglutide) are not compounded medications; they are FDA- approved products. Wegovy® is FDA-approved specifically for weight loss. Ozempic® is FDA-approved for Type 2 diabetes treatment but may be prescribed off-label for weight loss at the discretion of a healthcare provider.

Ozempic® and Wegovy® are registered trademarks of Novo Nordisk A/S. Nucore is not affiliated with or endorsed by Novo Nordisk A/S.

To ensure you receive the most appropriate care, all prescription products from Nucore Health require a confidential online evaluation with a licensed medical professional. They’ll carefully review your needs to determine if a prescription is right for you.

Important Information: The benefits you see on NucoreHealth.com are backed by independent third-party studies, though individual results can vary. Your medication is provided through a convenient subscription service you can cancel at any time. While the packaging might look a little different from what’s pictured, you’re always getting the high-quality medication prescribed for you. Once medical approval is in place (if needed), please allow 3-5 days for processing and shipping directly to your door.

Experience The Future Of Metabolic Optimization With Nucore.